Kakuzu might also be a main antagonist in this fanfiction. He's always after money and power. Maybe he sees Sakura as a valuable asset, either to sell her back to Konoha for a large sum or to use her skills for his own gain. He's not very empathetic and would likely be ruthless in his treatment of her.
Itachi himself could be seen as the main antagonist in this scenario as he is the one carrying out the kidnapping. He is acting against Sakura's will and causing a dangerous situation for her.
A rogue shinobi who has a personal vendetta against Sakura or her friends. Maybe this shinobi blames Sakura for something that happened in the past and decides to kidnap her as revenge. He could be a powerful and unpredictable antagonist.
There's also a possibility that Hinata's own clan, the Hyuga, would take matters into their own hands. They have their own unique techniques and a sense of pride. They would not allow the Akatsuki to keep one of their own captive for long and would send their strongest members to retrieve Hinata.
It could be Orochimaru. He has always been a major threat in the Naruto universe. If Sakura is on a mission while wearing the mask - like Kakashi, Orochimaru might be interested in her new look or the power she seems to be emulating. He could try to capture her to study her abilities or use her for his own evil purposes.
Kabuto could be an antagonist as well. He is a power - hungry character. If Naruto is trying to bring positive change to the Akatsuki, Kabuto's thirst for power and his underhanded tactics could put him in direct conflict with Naruto, as he might see Naruto as a threat to his own plans within the Akatsuki.
Well, in such a fanfiction, Sakura might be used as a bargaining chip. The Akatsuki could try to exchange her for something valuable, like secret jutsu. Or they might want to extract information from her about Konoha's defenses.
The Akatsuki members would be the main ones. It could include Itachi, who is known for his complex character and powerful abilities. His relationship with Sakura could be an interesting aspect, whether it's one of mutual respect or a more adversarial one.
It could be Orochimaru. He's always had an interest in powerful shinobi, and Sakura has shown great potential. Itachi might be roping Sakura's wrists to prevent Orochimaru from getting to her and using her for his evil experiments.
It could be Orochimaru. He has always been interested in Sasuke and might kidnap Sakura to use her as bait to get Sasuke back under his control. He could be after Sasuke's power and think that by using Sakura, he can manipulate Sasuke easily.
They might treat her harshly at first to break her spirit. But then, realizing her value, they could start to offer her deals, like freedom in exchange for her cooperation. However, Sakura is a tough character, so she'd likely resist their attempts.