Perhaps she wakes up as a male and discovers that she has different career opportunities. In a male - dominated field, she might suddenly find herself with more advantages, which makes her question the gender biases in society. She could also start to see the world from a male perspective, noticing how men are treated differently in various situations, like in sports or in romantic relationships.
Maybe in the story, the straight guy wakes up gay and suddenly finds himself attracted to a guy at his workplace. He then has to deal with the confusion and the potential reactions of his colleagues. It could involve him trying to figure out if it's just a passing phase or a real change in his sexuality. And depending on the choices in the interactive part, he could either explore this new side of himself or struggle to hold onto his old identity.
Well, it could be about a magical spell. Maybe he offended a witch and she turned him into a girl as a punishment. He then has to go through his day trying to figure out how to reverse it while dealing with all the new experiences of being female, like wearing different clothes and having different social interactions.
Well, it could be a story where Harry and Fleur are part of a secret mission together. They had to stay the night in a hidden place for safety. When Harry wakes up with Fleur, they might start discussing their next moves in a very friendly and perhaps a bit flirty way. They could exchange stories about their experiences at Hogwarts and Beauxbatons respectively, and then realize they have more in common than they thought.
In a more metaphorical sense, it might represent a character's sudden realization of having more masculine qualities or power. For example, she could be waking up to a newfound assertiveness or a sense of being in a male - dominated world where she has to adapt to male - like characteristics to survive or succeed.
One possible plot could be that the deaf man wakes up one morning. His wife has been unhappy in the marriage for a while. So, she decides to leave. Meanwhile, perhaps there was a neighbor or someone in their community who was ill. Since the deaf man might be a bit isolated because of his condition, he only finds out later that this man has died. And the story could be about how these events impact the deaf man's life and how he copes with it all.
One possible plot could be that the girl is a fellow student at Hogwarts who has fainted during a dangerous situation, like a duel gone wrong in a secret passage. Harry, being the heroic type, uses a spell to wake her up. Then they end up having to work together to get out of the passage before it closes or some other threat arrives.
It could be really confusing and overwhelming. He'd have to deal with all the societal expectations and differences that come with being a girl.
One possibility is that he wakes up and discovers new allies. The story could then revolve around him building relationships with these new characters while still holding onto his old values. He may also have to deal with the fact that the world has moved on without him and find his new place in it.
Perhaps he wakes up to find that the laboratory is in the middle of a big experiment gone wrong. There are strange creatures or phenomena around him, and he has to figure out how to escape and also stop whatever bad thing is about to happen. He might use his Pokémon knowledge and skills to get through this tough situation.
In the fanfiction, when Ash wakes up in the room, he might discover that he has new, unexpected powers. The room could be a sort of testing ground for him. He'll have to learn to control these powers while also dealing with the mysteries of the room, like hidden doors and cryptic messages on the walls.