In this fanfiction, there could be a villain who has the ability to manipulate Naruto's mind. The villain might use this power to make Naruto turn against the Hidden Leaf Village. Naruto, without control of his own mind, could start causing chaos within the village, like attacking important buildings or trying to steal important ninja secrets.
A new, unknown villain could be the cause. This villain might have a special power related to mind control or mental manipulation. They target Naruto because of his status as a hero in the ninja world. By making Naruto lose his mind, they could throw the entire ninja world into chaos.
In this fanfiction, it could be that the pressure of being 'The Chosen One' finally gets to Harry. All the battles, the losses he has endured, and the constant threat of Voldemort might push him over the edge. He could start acting erratically, pushing away his friends and allies because he no longer trusts his own judgment.
Well, he could start making really rash decisions. Maybe he'd attack his friends by mistake, thinking they were enemies. Since he's lost his mind, his usual judgment would be out the window.
A 'Naruto loses his memory fanfiction' might involve a mysterious curse placed on Naruto. He forgets not only his personal relationships but also his ninja skills. His sensei, Kakashi, could take it upon himself to reteach Naruto everything from the basics. Meanwhile, Naruto might form new, unexpected relationships with people in the village who don't know the 'old' him, and these new relationships could either help or hinder his journey to regain his memory.
Maybe Orochimaru manages to get his hands on Naruto and subjects him to some dark and twisted experiments. These experiments could mess with Naruto's mind, causing him to lose his sanity. He could start seeing illusions all the time, believing his friends are his enemies. As a result, he'd be in a constant state of confusion and aggression, and his once - positive attitude towards life and ninja - hood would be completely gone.
Maybe he loses his humanity as a result of a failed experiment. Some rogue ninja or a secret organization might try to enhance his power but end up corrupting his very essence. As a consequence, Naruto could start to show no mercy, lack empathy, and use his powers for destruction rather than protection.
In such a fanfiction, perhaps Naruto could be wrongly accused of something that leads to him being stripped of his birthright. Maybe a false claim about his connection to the Nine - Tails is used against him.
Well, one possible plot could be that Naruto is cursed by an enemy during a battle. This curse takes away his voice. As a result, he has to find new ways to communicate with his friends and allies. Maybe he starts using sign language, which he has to learn quickly. This could lead to some really interesting character development as he struggles to convey his thoughts and emotions without speaking.
One possible plot could be that Naruto is put under a powerful genjutsu. This genjutsu messes with his mind and slowly drains his emotions. As a result, he becomes detached from his friends and his sense of purpose. He no longer shows excitement for training or fighting, and his usual determination fades away.
In this fanfiction, it could be that Naruto's left - eye loss is part of a curse placed on him by an ancient evil. This curse not only takes his eye but also starts to drain his chakra. Naruto then has to search for the origin of the curse to break it. Along the way, he meets some new characters who either help or hinder him. His relationship with Sasuke could also be affected as Sasuke might see Naruto as weakened and try to protect him in his own way, which Naruto would initially resist as he doesn't want to be seen as a liability.