One idea could be a crossover with Sherlock Holmes. House could team up with Sherlock to solve a medical mystery that has some criminal elements involved. They could both use their deductive reasoning skills, with House focusing on the medical aspects and Sherlock on the overall mystery.
One idea could be House playing a medical simulation game in the hospital's VR system, and strange glitches start affecting real patients' diagnoses. Another could be a new intern who is a hardcore gamer and uses gaming strategies to solve medical mysteries, which both intrigues and annoys House. Or perhaps House enters a real - life 'escape room' that's set up like a complex medical case, and he has to use his skills to 'escape' by solving it.
A cool plot for 'the loud house crossover fanfiction' might involve a crossover with 'My Little Pony'. The ponies could come to Royal Woods, and the Loud sisters could be fascinated by their magic and cuteness. Lincoln might have to figure out how to get the ponies back to Equestria while also dealing with his sisters' excitement. Or perhaps the Loud family travels to Equestria and has to adapt to a world ruled by ponies.
The OC could also be a patient's family member. She comes to the hospital often to check on her relative and crosses paths with House. At first, House is just his usual sarcastic self with her, but she challenges him in a way that no one else does. They start to have secret conversations, and slowly a romantic relationship forms. However, they have to keep it under wraps because of hospital ethics.
One idea could be that Spongebob and Patrick end up in the Loud House world. They could be really confused by all the human stuff and the big family. Maybe they try to make a Krabby Patty in the Loud House kitchen but use the wrong ingredients and chaos ensues.
One idea could be a crossover with another popular animated show. For example, the characters from 'Loud House' could end up in a different universe where they have to use their unique skills from 'No Such Luck' to survive. Maybe they meet characters who have similar family dynamics but different challenges.
One idea could be that the misfortunes from 'No Such Luck' somehow cross over into an alternate universe in the crossover. For example, Lincoln's bad luck could start affecting the other characters from the crossover world in strange ways, like causing their gadgets to malfunction.
I also like 'When Hunters Meet Doctors'. It shows how the Winchesters would react to the medical world of 'House MD' and vice versa. The story has a lot of action as the brothers deal with the supernatural while also trying to work with the doctors who are skeptical of their claims. It keeps you on your toes as it jumps between the two different storylines.
Identity is also a common theme. The characters in both Twilight and House MD have strong identities. The doctors in House MD are defined by their medical knowledge and their flaws, while the characters in Twilight are defined by their supernatural nature. In the crossovers, there can be a lot of exploration of how these identities interact, change, or conflict when the two groups meet.
One common theme is the clash of different investigative styles. NCIS has its own set of protocols and House has his unorthodox methods. Another theme is the cooperation between two groups of strong - willed characters. And often, there's a medical mystery at the core that ties the two shows together.
One challenge is character integration. The characters from 'Supernatural' have a very different world view and set of skills compared to those in 'House MD'. For example, Sam and Dean are used to dealing with the supernatural, while House and his team are focused on medical diagnosis. So, finding a way to make them interact in a believable way can be tough.