Darkseid could be a formidable villain in this fanfiction. His goal of universal domination would bring him into conflict with Supergirl and Batman. He could send his minions to Earth to cause chaos and steal powerful artifacts. Supergirl and Batman would have to put aside their differences and join forces with other heroes to take on Darkseid and his forces.
Lex Luthor would be a great choice. He could be causing trouble in Gotham as well as Metropolis. His intelligence and resources would pose a significant threat to both Supergirl and Batman. He might be trying to manipulate events to make the two heroes fight each other so he can carry out his evil plans.
The Joker could also be a good villain. Imagine his chaotic nature meeting Supergirl's power and Batman's determination. He could try to play mind games with both of them, and his unpredictability would add a lot of tension to the story. Maybe he has a new toxin that affects Kryptonians in a strange way, which forces Supergirl and Batman to figure out how to stop him quickly.
Perhaps an interdimensional villain. This villain could be causing disruptions in both The Flash's and Supergirl's dimensions, forcing them to meet and join forces to stop it. The villain could have powers that are a challenge for both of their unique abilities.
Lex Luthor would be a great villain. He could be plotting to destroy Superman once and for all while also trying to outsmart Batman. His intelligence and resources make him a formidable foe for both heroes.
A powerful alien warlord could be the main villain. This warlord might have his eyes on Earth because of its resources or strategic location. Supergirl and Wonder Woman would have to use their unique powers and teamwork to defeat him. He could have an army of minions and advanced technology that makes him a formidable foe. They would need to figure out his weaknesses and come up with a plan to stop his invasion.
It could be someone like Ra's al Ghul. He is a powerful and complex villain that both Batman and The Shadow would have a hard time dealing with. His global influence and long - life plans would pose a great threat to their efforts to protect Gotham and the world.
Lex Luthor would be a great antagonist. He could play on the differences between Batman and Superman, trying to turn them against each other while he pursues his own evil plans. Maybe he creates a situation where it seems like Superman is a threat to Gotham, causing Batman to be on high alert.
Brainiac could also work well. He is an android with an insatiable thirst for knowledge and a penchant for collecting and destroying planets. In a crossover, he could target Earth, specifically Gotham and Metropolis. His advanced technology would pose a major challenge to both Superman and Batman. Superman's super - powers would be put to the test against Brainiac's powerful defenses, and Batman would need to use his wits to find a weakness in Brainiac's systems, leading to an exciting and complex story.
Lex Luthor would be a great choice. He could be plotting against both Batman and Supergirl. He might try to use his intellect to create a weapon that can nullify Supergirl's powers and outwit Batman's strategies at the same time.
Cheetah could be a great villain. She has a connection to Wonder Woman already, but in a crossover, she could be working with some of Batman's rogues like the Penguin. The Penguin could provide the resources while Cheetah does the dirty work in combat against Batman and Wonder Woman.
Lex Luthor would be a great choice. He's Superman's long - time nemesis. He could form an alliance with some of Batman's foes like the Joker. Luthor could use his intelligence and resources to create a plan that only Superman and Batman together could stop.
Maybe a corrupt businessman who discovers some ancient technology from the Old West that gives him superhuman abilities. He wants to use these abilities to take over Gotham and expand his business empire at any cost. He sees Batman as a threat to his plans and when the Lone Ranger shows up, he tries to get rid of them both. His greed and new - found powers make him a formidable foe for the two heroes.