In a fanfic, Hermione might initially be in denial. She would keep expecting Harry to return any day. She would go to their old haunts in Hogwarts, like the library or the Gryffindor common room, and just sit there, reminiscing. As time passes, she realizes she has to move on. She starts teaching at Hogwarts and imparts her knowledge and the values Harry also held dear to the new generation of students.
Another scenario in the fanfic could be that Hermione starts to mentor young witches and wizards. She wants to pass on the things she learned from her adventures with Harry. She could be very strict with them, because she doesn't want them to make the same mistakes she and Harry did. At the same time, she's always secretly hoping that one of these young students will have some idea on how to get Harry back.
Some might be shocked and feel betrayed. Harry is a hero to many, so his departure could leave them feeling abandoned. Others might understand his need for a break and respect his decision.
Some might be in shock. After all, Harry has been such an important figure in the wizarding world for so long. His friends like Hermione and Ron would probably be very worried about him and try to find out where he went. The Ministry of Magic could be in a panic, fearing that without Harry, they'll be vulnerable to new threats.
Some in the wizarding world might be shocked and disapproving, especially the more traditional families. They could see it as irresponsible given their young age and their roles in the fight against dark forces. However, their close friends like the Weasleys might be more supportive and offer practical help.
Well, it could cause quite a stir in the wizarding world. First, the relationship between Harry and Draco has always been complex and full of rivalry. If Harry leaves Draco for Ginny, the Malfoy family might feel a sense of victory in a strange way, as Draco has been in this sort of unspoken competition with Harry. For Ginny, it would be a big step forward in her relationship with Harry. And among their friends, like Hermione and Ron, they might have mixed feelings. Hermione might be worried about how this would change the dynamics among them all, while Ron would probably be more focused on how it affects Harry's happiness.
There's also 'Farewell to Magic' in which fem Harry leaves after a big magical war. She realizes that the wizarding world has changed too much and she can no longer find her place there. So she travels far away to a place where magic is just a faint memory and builds a new life from scratch. She has to learn how to adapt to a completely non - magical environment which is full of challenges but also new opportunities.
Some authors write it because they want to explore different character arcs. Harry's character is so iconic in the original series. By making Harry female and having her leave the wizarding world, they can create new and unique storylines that deviate from the traditional narrative.
Hermione's friends, like Harry, would likely be very protective of her. They might try to keep the news from spreading too far and help Hermione in any way they can. As for Draco, his family's reaction could be complicated. They might see this as an opportunity to gain some sort of advantage over the Weasleys, or they might be more sympathetic to Hermione's situation depending on how Draco feels about her.
It could cause a great deal of shock and gossip. The Weasley family, especially Bill's siblings, would likely be very angry and confused. There might be a rift between the Weasleys and Fleur, and perhaps even some tension between the Weasleys and Harry. After all, Bill is a well - liked member of the wizarding community.
One possible reason could be a creative plot twist by the fanfic writer. Maybe they want to explore how Harry would grow and develop on his own without Hermione's support. Another reason might be to introduce new and different story arcs that involve separation, like Hermione having to leave for a dangerous mission that she can't involve Harry in.