Well, perhaps Sakura is Itachi's sister but was separated from him at a young age. As she grows up in Konoha, she starts to have strange dreams and abilities that she can't explain. Eventually, she finds out about her relation to Itachi. This discovery makes her question her identity and her loyalty. Does she side with Konoha where she grew up, or does she try to avenge her brother and the Uchiha clan by joining forces with those who oppose Konoha?
A really interesting plot might be that Sakura, as Itachi's sister, has been secretly protected by Itachi all along. When Itachi dies, she sets out on a journey to understand her brother better. Along the way, she uncovers secrets about their family and the Uchiha clan that no one else knew. This could lead to her becoming a key figure in mending the relationship between the remaining Uchiha and the rest of Konoha.
The plot could center around Sakura's role in Itachi's decision - making. Since she's his older sister, she has a certain influence over him. Maybe she has a different view on the Uchiha's situation compared to the elders in the clan. She could be the voice of reason for Itachi, guiding him to find a more peaceful solution to the clan's problems. For example, she could encourage Itachi to negotiate with the village leaders instead of following the orders blindly. And in the process, her relationship with Itachi would be explored deeply, showing their bond as siblings.
One plot idea could be that Itachi and Shisui are on a mission and they cross paths with Sakura. Shisui, being the friendly one, starts to teach Sakura some new jutsu skills. Itachi, initially reluctant, gradually warms up to Sakura's determination. Another could be a time - travel plot where Sakura goes back in time and meets a young Itachi and Shisui. She tries to prevent some of the tragedies that are to befall them in the future. And finally, a plot where Itachi and Shisui are in a life - or - death situation and Sakura, with her medical skills, has to save them and in the process, they form a strong bond.
One plot idea could be that Sakura, a young doctor, discovers Itachi is a vampire when he comes to her for help after being injured in a fight with vampire hunters. She is initially afraid but then becomes intrigued by his complex personality.
Perhaps there is a plot where an ancient curse is affecting the Uchiha clan, and Itachi and Shisui suspect Sakura might have some knowledge or power that could help them break it. They then team up with her to find a solution, and along the way, they discover new aspects of each other's personalities and abilities.
One idea could be that Itachi, in a possessive way, protects Sakura from unseen threats in the ninja world. Maybe he secretly follows her on missions and takes out any enemy ninjas before they can reach her.
A plot could involve Sakura getting caught in a political intrigue within the Anbu that Itachi is also a part of. Itachi tries to keep Sakura out of it, but she's determined to uncover the truth. This leads to a series of events where they have to rely on each other's strengths and overcome their own weaknesses.
Another plot idea could be that the contract was made by an ancient force and it requires them to go on a quest to find a lost artifact. Along the way, they face many challenges and their relationship changes from initial distrust to a strong friendship or even something more. They have to rely on each other's strengths and overcome their weaknesses.
One idea could be that Itachi is a new transfer student in Sakura's highschool. Sakura, being the studious and kind - hearted girl she is, is assigned to help Itachi catch up with the lessons. This could lead to them gradually developing a friendship and maybe more as they discover each other's secrets and talents.
A plot could involve Itachi's spirit being re - summoned in a way that only Sakura can interact with. Sakura, with her medical knowledge, tries to find a way to bring Itachi back to life fully. During this time, they share many memories and Sakura starts to consider Itachi as part of her family. The story could then revolve around Sakura's attempts and the consequences it might have on the ninja world.
Maybe there's a school event like a cultural festival. Itachi, who is usually reserved, could show his hidden talents during the preparation for the event. Sakura gets impressed and they start to bond over their shared love for the festival spirit. They might face some jealous classmates who try to break them apart, but in the end, their relationship grows stronger.