Perhaps a rogue ghost who has managed to hack into Cybertronian technology. This ghost, let's call it Techno - Ghoul, has the ability to possess and control Transformers. He starts causing chaos by making Autobots and Decepticons fight each other. Danny Phantom has to use his ghost - hunting skills and his knowledge of both the human and ghost worlds to find a way to exorcise Techno - Ghoul from the Cybertronian systems.
It could be Sam and Tucker. Since Danny has become a villain, his former friends would likely try to stop him. They would be the main antagonists from Danny's point of view now. They would use their knowledge of Danny and their own skills to try and bring him back to the good side.
The main villain could be an older and more powerful version of Vlad. Maybe he has finally perfected his cloning techniques and created an army of half - ghost clones. He could be more devious and have a grand plan to take over both the human and ghost worlds.
A powerful warlock who wants to harness the powers of both Danny and Carrie for his own evil purposes. He could be an ancient being who has been waiting for the right time to strike when both Danny and Carrie are at their strongest.
Vlad Masters could easily be the main villain. Since he already has his own ambitions and a certain amount of power, in a royal - themed fanfiction, he could be trying to take over the ghostly royal throne. He might see Danny as a threat to his plans, especially if Danny has some newfound royal status, and thus plot against him.
A possible main villain could be a dark wizard from Star's world who has somehow gained the ability to control ghosts. He could use this power to try and take over both Danny's world and Star's, seeing the combination of magic and the ghost zone as a means to ultimate power.
One possible plot could be that Danny Phantom, while exploring the Ghost Zone, stumbles upon a portal that leads to the Transformers' universe. There, he teams up with the Autobots to fight against a new threat that is related to both ghosts and the Decepticons. For example, a Decepticon scientist could be experimenting with ghost energy to create powerful weapons, and Danny's ghost powers are needed to stop it.
Perhaps a mad scientist from Danny's world who has somehow gotten access to Ultraman technology and is using it to create chaos. He could be creating mutant creatures that are a threat to both the Ghost Zone and Ultraman's world, and Danny and Ultraman have to stop him before it's too late.
One idea could be that Danny's ghost powers somehow interact with the Cybertronian technology in the Transformers Prime universe. Maybe his ectoplasmic energy can power up or disrupt certain Cybertronian devices. For example, he could accidentally short - circuit a Decepticon weapon while trying to use his powers to protect a human from an attack.
Danny would be one of the main characters, no doubt. And from the Sekirei series, Musubi could be a key character in the fanfiction. She is one of the more prominent Sekirei, being kind - hearted and strong. Her naivete might lead to some humorous situations when she first meets Danny. Also, Tucker Foley from Danny Phantom could be another main character. He could use his tech - savvy skills to help in the Sekirei world, perhaps by creating some new gadgets that work in that universe as well.
A powerful ghost who has found a way to corrupt Pandora's magic could be the main antagonist. This ghost might want to use Pandora's magic to gain more power in the ghost zone and the human world. It could start by causing chaos on Pandora, and then Danny would have to step in to stop it.