Another plot twist could be related to the pregnancy itself. What if Sakura's pregnancy was not a natural one but rather the result of some kind of experiment or curse? This could lead to a whole adventure where she has to find a way to break the curse and save her unborn child. She might have to team up with unlikely allies and face powerful enemies in the process.
One possible plot twist could be that the pregnancy is a result of some sort of ancient jutsu gone wrong. Maybe a forbidden technique that was meant to save Madara's life but instead had the side effect of causing Sakura to become pregnant. Another could be that an enemy has somehow manipulated their DNA to create the pregnancy as part of a grand scheme to control the two powerful shinobi.
One possible plot twist could be that Sakura discovers Kakashi has a secret past she never knew about. Maybe he was involved in some kind of dangerous mission long ago that has consequences in the present. This could put a strain on their relationship as she tries to come to terms with this new information.
Perhaps there could be a rival who tries to break them apart. This rival could be someone from Sasuke's past who has a grudge against him and sees Sakura as a way to get revenge. They might spread false rumors about Sasuke to make Sakura question his loyalty.
One possible plot twist could be that right before the wedding, Naruto has to go on a dangerous mission. This could put their relationship to the test as Sakura has to deal with the fear of losing him. She might even consider calling off the wedding. Another plot twist could be that an old enemy resurfaces and tries to use Sakura as a leverage against Naruto, forcing him to make a difficult choice between his love and the safety of the village.
One possible plot twist could be that the pregnancy is not a normal one. Maybe it's part of some alien experiment or a time - related anomaly. For example, the baby could have special powers that are both a blessing and a danger. Another twist could be that the Doctor has to make a difficult choice between saving Amy and the unborn child in a life - threatening situation.
One possible plot twist could be that Caroline initially tries to keep it a secret from Klaus. She might be afraid of how he'll react or what it means for their complicated relationship. But then, circumstances force her to tell him, like a threat from an enemy who somehow finds out about the pregnancy.
One possible plot twist could be that Hancock has to hide her pregnancy from the outside world for the safety of Luffy and their unborn child. Maybe there are enemies who would target them if they knew. Another could be that Luffy has some strange reaction to the news of becoming a father, like initially being really confused but then growing into the role in an unexpected way.
One possible plot twist could be that the pregnancy is not a normal one. Maybe there are some special powers or abilities that the baby inherits which causes all kinds of chaos and challenges. For example, the baby could have the power to manipulate time like Alice, but it's out of control in the womb and affects the flow of time around them.
One possible plot twist could be that the pregnancy is unexpected and it forces Luffy and Nami to reevaluate their relationship within the Straw Hat crew. For example, they might have to deal with how their crewmates react, especially those who are protective of Nami like Sanji. Another twist could be that there's some sort of magic or mystery involved in the pregnancy that endangers Nami and the baby, leading Luffy on a quest to find a cure or solution. It could also be that the pregnancy is a false alarm due to some villain's scheme, creating chaos and misunderstandings within the crew.
One possible plot twist could be that they initially plan to keep the pregnancy a secret but then someone discovers it and spreads the news, causing chaos in their lives. Maybe their families have different reactions, with some being supportive and others not so much.