In this fanfiction scenario, they could run away because of a false accusation. The village might think they are responsible for a major crime they didn't commit. Sasuke, with his Sharingan, Naruto, with his Nine - Tails chakra, and Sakura, with her medical skills, make a great team on the run. They might encounter an old enemy who decides to help them prove their innocence as they all have a common goal against the real culprit.
One possible plot could be that they run away from the Hidden Leaf Village to avoid a powerful enemy that is targeting them specifically. Maybe this enemy has some vendetta against them because of their unique abilities or past actions. They might have to rely on each other's skills and their friendship to survive in the wild and find a new place to call home.
Perhaps in this fanfiction, Sasuke, Naruto, and Sakura run away because they discover a dark secret within the village that they can't bear to be a part of. They feel that the only way to expose this truth or protect themselves is to flee. As they run, they face various challenges like natural disasters and other ninja clans who are after the bounty on their heads. They grow closer as a team during this journey.
Well, they could embark on a journey to discover a hidden ninja village that holds the key to a powerful jutsu. Along the way, they might face various challenges like traps set by rival ninja clans. And Naruto would probably be the one to keep everyone's spirits up with his positive attitude.
A simple reason could be to escape a dangerous prophecy. Maybe there's a prediction that they will cause great harm to the village if they stay, so they run away to figure out how to change their fates.
For Naruto, running away might make him more determined to prove his worth and protect his friends. He could learn to control his Nine - Tails chakra better in the face of danger outside the village. Sasuke may start to trust Naruto and Sakura more, realizing that they are his true comrades. Sakura, on the other hand, could become more independent and confident in her abilities, not just relying on Sasuke and Naruto but also being able to take charge when needed.
A plot could be that they are being hunted by a powerful and evil ninja organization. So they run away to gather strength and allies. Naruto might try to convince some of his old friends from other villages to join their cause. Sakura would be constantly worried about their safety but also determined to fight back.
They might run away to avoid a conflict that their villages are about to be dragged into. Naruto and Sasuke, being the powerful ninjas they are, don't want to be used as tools in a war, so they decide to run away.
Well, perhaps in a 'naruto and ino run away' fanfiction, they run away because they discover a dark conspiracy within the village that targets them. They run to find an ally in a far - off land. As they journey, they start to rely on each other more. Ino uses her mind - reading skills to avoid enemies, and Naruto uses his strength to protect them during battles.
Maybe they run away to avoid an arranged marriage. Sakura, being strong - willed, leads the group. Ino could use her mind - transfer jutsu to gather information on safe places to hide. Hinata is there for her gentle support, and Tenten provides her weapon - skills for protection. They end up in a hidden valley where they train in secret.
One possible plot could be that Naruto and Sasuke run away to find a place where they can train without the interference of the Hidden Villages. They might be on a quest to become stronger together, away from the prying eyes of their respective villages which have different expectations of them.
Well, it could be about Naruto and Sakura finally having to face Sasuke who has gone too far in his pursuit of power. Maybe Sasuke is causing chaos in the village and they have no choice but to stop him.
A possible plot could be that they discover a new and dangerous jutsu that has been lost for centuries. They decide to train together to master it so that it can be used for the good of the village. Along the way, they learn more about each other's pasts and their friendship deepens.