The interaction between Naruto and Blake could be fascinating. Blake has her own dark past and Naruto has his own struggles with being an outcast at times. They could bond over their shared experiences of not always fitting in. Naruto's ability to never give up on his friends could inspire Blake, and Blake's intelligence and reading habits could introduce Naruto to new ideas and ways of thinking.
I think Naruto and Weiss would have some great interactions. Weiss is from a high - class family and is very proper, while Naruto is this rough - around - the - edges ninja. Their clash of cultures could lead to some really funny and also some really deep moments. Maybe Weiss could teach Naruto about the importance of elegance in combat, and Naruto could teach Weiss about the value of hard work and determination from his own experiences growing up.
Naruto and Ruby would be really interesting. Ruby is young and full of energy, much like Naruto. They could bond over their shared enthusiasm for protecting others. Naruto could show Ruby some of his cool ninja moves, and Ruby could introduce Naruto to Crescent Rose. Another interesting interaction would be between Sakura (from Naruto's harem) and Weiss. Weiss is from a wealthy family and is very proper, while Sakura is a strong - willed medical ninja. They could have some really fun arguments and also learn from each other's skills.
I think the interaction between Ruby and Ben would be really interesting. Ruby is very energetic and has a strong sense of justice. Ben, with his experience of using the Omnitrix to save the day, could share some of his stories with her. They could also have some friendly competitions regarding their combat skills, like who can take down a group of Grimm faster, with Ruby using her Crescent Rose and Ben using one of his alien forms.
Deadpool and Yang could also be really interesting. Yang is tough and has a bit of a hot - headed side. Deadpool would probably egg her on in fights, and she'd either be really annoyed or find his bravado kind of cool. They could have some epic battles together against the Grimm, with Deadpool making inappropriate jokes all the while.
The interaction between Iron Man and Kakashi would be really interesting. Kakashi is a very intelligent and experienced ninja, and Iron Man is a genius inventor. They could exchange ideas about combat strategies and knowledge from their different worlds.
Definitely Iron Man and Ruby. Ruby is young and full of enthusiasm, while Iron Man is a genius billionaire. Their interactions could be really fun as Ruby would be in awe of his technology, and Iron Man would be impressed by Ruby's determination and natural combat skills. He might even see her as a little sister figure and mentor her in some ways.
Another interesting interaction could be between Red Hood and Blake. Blake, with her Faunus background and her own complex views on justice, could have some really deep conversations with Red Hood. They might debate on when it's okay to take extreme measures in the name of justice.
I think Axel and Yang would have a cool interaction. Axel with his pyro abilities and his somewhat edgy personality could clash and also bond with Yang, who is hot - tempered and has her own fire - based powers. They could have some great banter and also team up in battles, with Axel using his acrobatic fighting style and Yang using her brawler moves.
One of the most interesting interactions would be between Bayonetta and Hinata. Hinata's shy nature would be a stark contrast to Bayonetta's boldness. Bayonetta could inspire Hinata to be more confident in herself. Also, the interaction between Rock Lee and Bayonetta would be fun. Rock Lee would be eager to prove himself to her in combat, and Bayonetta would be entertained by his enthusiasm and unique fighting style.
Definitely Naruto and the Little Sisters. Naruto has a soft spot for those in need, and the Little Sisters are in a very vulnerable position. He would probably be very protective of them, and the contrast between his energetic and positive personality and their rather timid and strange existence would be fascinating.
Kakashi and an older, wiser character from Serenity's world could be a great interaction. Kakashi is known for his wisdom and combat skills. Meeting someone with different knowledge and abilities from another world could lead to some deep conversations about life, strategy, and the nature of their respective universes.