With Naruto, their friendship would likely become more complex. Naruto might initially be shocked but then become very protective. Their rivalry could also take on a different tone, perhaps less about pure power and more about Sasuke's secret and how Naruto can help keep it. As for Sakura, she might be jealous at first if she discovers Sasuke's true gender and realizes that Sasuke has been hiding this from her. But she could also become a closer friend as they share more feminine experiences.
If Sasuke is secretly a girl in the fanfic, her relationship with Kakashi would be different too. Kakashi, being a perceptive teacher, might suspect something but not say anything at first. He would probably be more cautious in how he trains Sasuke, taking into account the extra challenges she might face as a girl in a male - dominated ninja world. And with the other members of Team 7, like Sai, Sasuke's secret could create a whole new dynamic of trust and secrecy within the team.
Her relationship with Naruto would be different. Instead of the typical male - male rivalry, there could be a more complex dynamic. Naruto might be more protective of her at times, or there could be a romantic undertone to their friendship. With Sakura, they could become closer as two strong female characters. Sakura might see Sasuke as an inspiration for her own growth. And with Kakashi, he would have to adjust his mentoring style as Sasuke is now a girl, perhaps being more cautious and aware of the different challenges she might face.
In a family setting, her relationship with her parents might also shift. Her father might become more protective, while her mother might start to have more mother - daughter type of conversations with her. And with siblings, there could be new dynamics depending on whether they are older or younger. If she has an older brother, he might be more protective too, and if she has a younger sister, they could become closer as sisters often do.
In terms of her enemies, they might try to use her gender against her. They could spread rumors or try to undermine her in battles by taunting her about her secret. However, this could also backfire as it might make her more determined to prove herself as a strong fighter regardless of her gender.
Well, with Kakashi, he might be more cautious in how he trains Sasuke. As a girl, Kakashi might have to consider different aspects of training, like physical limitations that might come with the female form. His relationship with his clan members, if they were still around, could also be different. They might have different expectations of a female Sasuke. And when it comes to the other male ninja in the village, some might be attracted to him, which would create some awkward or interesting situations.
If Tsuna were a girl, her relationship with her male friends might become more complex. For example, some of them might develop romantic feelings for her. Her friendships with female characters could also change. They might become more competitive or more sisterly depending on the nature of the story.
When Shirou turns into a girl, her relationships with other characters are bound to be different. Her male friends might start to see her in a more delicate way, even if she still has her old - Shirou - like strength. There could be a change in the power dynamics within the group she belongs to. Her relationships with female characters could range from being mentored by them in how to be a girl to facing competition from them. And any romantic relationships she had or hoped for would need to be re - examined, as the gender roles and expectations are now different.
If Arthas turns into a girl, her relationships with male friends might become more complex. For example, some might see her in a new, romantic light. Her friendships with female characters could also change. They might be more empathetic towards her situation or be jealous of her new - found attention.
In relation to Black Widow, they could form a stronger bond. Black Widow might see in her a kindred spirit, now that they are both female superheroes. They could train together more often, share secrets about being a woman in a tough superhero world, and team up more effectively during missions.
If Naruto were a girl, her relationship with Sasuke would likely be more complex. There could be an underlying romantic tension from the start. Sasuke might be more protective of her. And with Sakura, instead of a love triangle, they could become best friends who support each other in their ninja careers. Also, Kakashi might train her a bit differently, perhaps being more lenient at times because of her gender.
In terms of her relationships with other Slytherins, the boys in the house might either be overly protective or try to take advantage of her. Some of the Slytherin girls might see her as a threat, especially if she's getting more attention from the boys or from the teachers. But there could also be a group of Slytherin girls who form a strong clique with her. And her relationship with Dumbledore could be one where he tries to encourage her to break free from the more traditional and sometimes dark Slytherin values, seeing her as a potential force for good in the house.