Perhaps a corrupted Hogwarts professor. They might be afraid that Harry will find out their dark secrets hidden in the lost library, so they become the antagonist and try to keep Harry away from it. They could set up various traps and obstacles for Harry.
It could be a dark wizard who also wants to get to the secrets in the lost library. This wizard might try to stop Harry from exploring the library and getting its knowledge.
In this fanfiction, there could be an ancient evil spirit bound to the library. It doesn't want anyone, especially Harry Potter, to disrupt its slumber or access the powerful knowledge in the library. So it becomes the main force opposing Harry as he tries to explore the lost library.
Well, perhaps in the 'Harry Potter finds a lost library' fanfiction, the library is magically protected. Harry could encounter some magical creatures that are guardians of the library. He might also use his Parseltongue ability to unlock a special part of the library, leading to a discovery that changes the course of his fight against the Dark Arts.
It could be a dark wizard who wants to get his hands on the lightsaber for its power. He might see it as a new tool to use in his evil plans, like using it to break into Gringotts or to fight off any who oppose him.
It could be a dark wizard who also has an interest in the snake. Maybe he wants to use the snake's powers for evil purposes, like opening a portal to a dark dimension or controlling other magical creatures. So he becomes the main obstacle for Harry as he tries to protect the snake.
It could be a dark wizard who has also found his way into space. This wizard might be using the new environment to develop even more powerful and dangerous dark magic.
It could be Captain Hook. Since Harry Potter has magic, Hook might see him as a huge threat to his plans in Neverland. He would try to capture Harry and use his magic for his own evil purposes, or simply get rid of him to maintain his control over the island.
It could be a dark wizard who has some connection to the sea. Maybe he wants to stop Harry from reaching a certain destination in the sea.
Perhaps a magical creature that has made the island its territory. This creature doesn't want outsiders like Harry and his friends interfering. It sees Harry's glasses as a strange and foreign object and will do anything to keep them from leaving the island. It could be a giant spider - like creature that spins webs to trap intruders, just like the acromantulas in the Harry Potter series.
In this fanfiction, the main antagonist could be an ancient evil that has been trapped within the grimoire. Once Harry finds the grimoire, this evil starts to gain power and tries to use Harry to break free completely and spread chaos in the wizarding world.
It could be a new dark wizard who has been secretly searching for the Death Stone. Maybe someone who was in the shadows during Voldemort's time and now sees an opportunity to rise with the power of this stone.
It could be Voldemort. Imagine he gets wind of Harry having this powerful Wolf Zord. He would stop at nothing to get it for himself, seeing it as a means to finally defeat Harry and take over the wizarding world completely.