One possible reason could be a misunderstanding. Maybe Harry misinterprets Draco's actions or words in a way that makes him do something that breaks Draco's heart. For example, if Draco is secretly trying to help Harry but Harry thinks he has some malicious intent and publicly shames him.
Perhaps it's a matter of unrequited love. If Draco has developed feelings for Harry but Harry is completely oblivious to it and starts dating someone else like Ginny, it would be a huge blow to Draco and break his heart.
Draco might become withdrawn. He could isolate himself from his friends and spend more time alone in the Slytherin common room, brooding over what Harry has done to him.
Perhaps Katara falls in love with someone else. In a fanfiction scenario, she might meet a new character who she feels a stronger connection with. This new relationship could cause her to break things off with Aang, shattering his heart in the process.
Maybe it's because of their different outlooks on life in the wizarding world. Hermione is very much about following the rules and using magic for good and knowledge, while Draco has been more influenced by the power - hungry and sometimes underhanded ways of his family. This could lead to constant arguments and ultimately a break - up.
One possible reason could be a newfound understanding between them. Maybe they've both grown and realized that their past enmity was pointless. They might have had some shared experiences that made Harry see Draco in a different light, and thus he was willing to accept his hand as a sign of peace or new friendship.
One reason could be love. Draco might have fallen deeply in love with Harry and his possessiveness is a way of showing his strong feelings. He doesn't want to lose Harry to anyone else.
One possible reason could be their long - standing rivalry. Draco has been taught to dislike Harry from a young age due to their family differences. His pure - blood supremacist upbringing might make him reject Harry as a mate because Harry is seen as a 'Mudblood - lover' in the eyes of Draco's family and their circle. Another reason could be fear. Draco might be afraid of what the wizarding society would think if he accepted Harry as his mate. The wizarding world has its own set of norms and expectations, and a relationship between them would be highly unconventional and likely face a lot of opposition.
Perhaps Tonks starts dating someone else, like Remus Lupin. Harry has some unspoken feelings for Tonks, and seeing her with Lupin makes him feel heartbroken. In the fanfiction, it could show Harry's internal struggle to accept the situation and his pain at seeing the woman he cares about with another man.
One possible plot could be that Snape reveals some long - held secret about Harry's parents in a very cruel way. For example, he might tell Harry that his father was not as heroic as he thought, and this shatters Harry's idealized view of his family, thus breaking his heart.
Well, it could be that Edward, perhaps jealous of Harry's popularity or a girl he likes, spreads false rumors about Harry. This causes Harry to be ostracized and his heart to break as he loses friends and respect.
Maybe Draco says some really mean and hurtful words to Harry. For example, he might make fun of Harry's family situation, like his parents' death or his relationship with the Dursleys. Words like that can be really cutting and could easily make Harry cry.