With the villagers of Konoha, Naruto was once seen as a hero. But his leaving could cause mixed feelings. Some might see it as a betrayal, while others might respect his choice. Fem Sasuke was always an enigma in Konoha. Her leaving might be seen as expected by some, but for those who hoped she would fully integrate into the village, it would be disappointing. And as they journey outside Konoha, they will meet new characters, and their relationships with them will be based on their new identities as outcasts from Konoha.
In terms of their relationship with their families, if they have any remaining family members. Naruto's family, like Jiraiya (if he's still alive in this fanfiction) could be overjoyed and offer all kinds of support. Sasuke's family, perhaps Itachi (again, if alive) might have a more complex reaction, being both proud and worried about the future of the Uchiha bloodline with this new development.
Well, their friends in Konoha would be really sad. For Naruto, his friends like Sakura and Shikamaru would feel betrayed at first. They might not understand why he left without saying much. But later, they might start to suspect that there are deeper reasons and some of them might even try to find out the truth and support Naruto from afar.
They may leave to investigate a mystery that has long been ignored or covered up by Konoha. This could be related to the origin of certain powerful jutsu or the real history of some important clans. Their departure from Konoha is a way to break free from the village - imposed limitations on knowledge and seek the truth on their own.
As for Kakashi, he would be in a difficult position. He has mentored Naruto and also has a strong loyalty to Konoha. He might try to understand Naruto's reasons while also having to deal with the village's reaction. Their relationship could become strained as Kakashi tries to balance his duties to the village and his connection with Naruto.
The relationship between Fem Naruto and Sasuke might be different. Sasuke might be more protective of her at first because she's a girl. And Fem Naruto might have to work harder to prove to Sasuke that she's just as strong. With Sakura, they could become closer friends as they might bond over girl - related things like fashion or gossiping about other students, while still having their ninja - related rivalries.
Well, fem Sasuke might be more in touch with her emotions compared to the original Sasuke. She could show vulnerability more easily. Naruto, on the other hand, might become more protective. For example, he might be quicker to jump into a fight if fem Sasuke is threatened.
Perhaps in a fanfiction, Sasuke discovers a new and extremely dangerous power that he can't control and it starts to endanger Konoha. Naruto tries to stop him but in the heat of the battle, accidentally kills him. Overwhelmed with guilt and feeling that the village will never understand, Naruto leaves. But this is a very different take on their relationship and the Naruto world as a whole.
Well, their relationship with Sakura could become more strained. Since they left, she might feel abandoned and angry at them at first. But later, she could also come to understand their reasons. With Kakashi, he might be disappointed in them for leaving, but also secretly hope they find their own path. As for their enemies outside the village, they might start to see Naruto and Sasuke as more of a threat since they are no longer bound by the village's rules.
On the other hand, their relationships could grow stronger. Away from the rules and expectations of Konoha, they rely more on each other. Naruto and Sasuke could finally understand each other better. Sakura, with her medical skills, becomes even more important to them. They start to trust each other more deeply, and their bond as a team becomes unbreakable. They might have heart - to - heart conversations that they never had in Konoha.
Well, their relationship with Kakashi would be different. Instead of just being their teacher, he might see them more as a family unit. He would have to deal with their sibling dynamics, like Naruto and Sasuke's competitiveness and Sakura trying to keep the peace between them.