Definitely not. Pressing a signed comic is a bad idea. It could ruin the autograph, affect the paper quality, and make the comic less valuable to collectors. You should handle it with care and keep it in a protective sleeve or frame.
No, you shouldn't. Pressing a signed comic might smudge the ink, cause creases, or otherwise harm the collectible nature and integrity of the item. It's best to store it properly without applying any pressure.