Well, in a comic, the difference could be depicted visually. Conductors might be shown as shiny, connected wires that carry energy, while insulators could be like rubber or plastic that stop the flow. Another aspect could be how heat moves through them - conductors transfer heat well, insulators don't.
The comic might show that insulators keep you safe from electric shocks because they don't conduct electricity. Conductors, on the other hand, are needed to transfer power. Maybe it'll illustrate that conductors are used in circuits, but insulators are used to protect you and prevent short circuits.