As of now, the three highest box office earnings in the world were: 1 Titanic (Titanic was released in 2017): Global box office earnings of about 46.3 billion US dollars. 2. Avengers: Endgame (2019 release): Global box office earnings of approximately $45.7 billion. Avatar (released in 2009): Global box office earnings of about 42.7 billion US dollars.