The Wei, Jin, Southern and Northern Dynasties was a period of cultural, political and social unrest. Under this background, people's quality of life declined, psychological pressure increased, and health problems gradually became a problem that could not be ignored. The cultural background of the Wei, Jin, Southern and Northern Dynasties was different from that of modern society. At that time, people paid more attention to individual freedom and personality, but social pressure was also greater. Coupled with the influence of war and natural disasters, people's health was greatly affected. Political unrest was also one of the main causes of health problems. During the Wei, Jin, Southern and Northern Dynasties, the political situation was chaotic and the society was divided. The various political powers attacked each other, and the wars and turmoil continued. In this environment, people's living conditions and mental health were also affected. In addition, the medical and health standards in the Wei, Jin, Southern and Northern Dynasties were relatively low. People lacked sufficient medical and health care knowledge and did not pay enough attention to the prevention and treatment of diseases, which also led to many people dying of health problems during this period. To sum up, the Wei, Jin, Southern and Northern Dynasties was a period of cultural, political and social unrest. People's health was affected by many factors, so this period was called the "Age of Sickness".