Tower of Babel, Love Is a Dog, and 21 Grams were called the Estrangement Trilogy because these three novels crossed different cultural, social, and historical backgrounds to make readers feel the existence and influence of estrangement. Babel Tower was a science fiction novel that described a future world where humans connected different worlds and civilizations through a tower, but this also brought about estrangement and misunderstanding. This novel was considered a classic of science fiction and had won many awards and good reviews. Love Is a Dog is a modern novel about a girl who faces cultural differences, identity and sexism as she grows up. The novel transcended different social classes and cultural differences to show the reality and influence of the gap in the era of global integration. 21 Grams was a novel about time travel and memory. The concept of time travel and the reconstruction of memory in the novel were very creative, but they also led to the discussion and thinking of the nature of time and memory. The film had won many awards and was considered a typical sci-fi film. These three films showed the existence and influence of estrangement on different levels. From different perspectives such as science fiction, modern times and novels, they explored the thoughts and practices of people facing estrangement in different cultures, societies and historical backgrounds. Therefore, these three films were considered the representative works of the Estrangement Trilogy.