The relationship is rather loose. While comics could potentially be mentioned or referenced in passing in the Big Bang Theory, they aren't a central theme of the show. It's more about the characters' lives and relationships in a scientific context.
There's not a direct connection. Comics and the Big Bang Theory are in different domains, but some comic-related topics might come up in the show.
Chapter 870, "She is My Ex-Girlfriend", is the clearest early answer because it turns Xue Wandeng's situation into a concrete plot event. It opens with Huo Shan couldn't believe it and covered her mouth in shock.
Chapter 44 is the strongest chapter-level answer because it starts from But the next move by the production team proved they hadn't forgotten the... and follows through on Does anyone here know how to drive?.
Chapter 33 is the strongest chapter-level answer because it starts from Following the announcement, five artists respectively reposted the Weibo—... and follows through on Although Su Yinwan was considered half a goddess to him, the whole thing....
Chapter 866, "Why don't you die in his place?!", is the clearest early answer because it turns Chen Nanqing's situation into a concrete plot event. The chapter turns that into something concrete by moving from In Shuiyun Temple, Changqing silently watched everything happening in...
A practical answer is Chapter 47, because it turns the idea into a concrete scene. The chapter opens with Qi is actually second???] [Did the production team make a mistake?, adds pressure through The internet is so chaotic, all that previous slander might as well have..., and ends on Qi is so.
Chapter 904, "Welcome Young Master and Young Madam!", is the clearest early answer because it turns Jiang Bufan's situation into a concrete plot event. The chapter turns that into something concrete by moving from Jiang Bufan and Jiang Buchen immediately ran up in surprise.
If you want the clearest chapter reference, go to Chapter 35. Early on, Shining Transformation Trip's filming location was set on the distant...; later, the chapter leans on In order to help the guest stars get better acquainted with one another,....
A practical answer is Chapter 13, because it turns the idea into a concrete scene. The chapter opens with Sensing that something was off with Jiang Yan, Jiang Yan dismissed the..., adds pressure through He probably had a good guess who it was., and ends on How could this happen..." Lin Manru.
Chapter 803, "Younger Brother Misses Mom", is the clearest early answer because it turns Grandpa's situation into a concrete plot event. It opens with Brother, do you think hiding here is a bad idea?" "Don't worry,... and closes on It was as if she had been replaced by a different person..
Chapter 14 is the strongest chapter-level answer because it starts from Lin Manru had a rare good night's sleep. and follows through on But clearly, Lin Manru was unable to accept that her delicate daughter had....