He could also be a bit intrigued. Harry running away might mean there is something bigger going on that Snape doesn't know about. So, he might start investigating more thoroughly, using his skills as a Potions master and his knowledge of Hogwarts' secrets. He may even use his spy skills that he developed when he was working for Dumbledore.
Snape would likely be angry at first. Harry has always been a source of trouble in his eyes, and running away would just add to that perception. He might mutter some sarcastic remarks under his breath about Potter's irresponsibility.
Snape's reaction would be complex. On one level, he would be annoyed and perhaps feel that Harry is being a typical, disobedient student. However, he also has a sense of duty. He would realize that Harry is an important part of the wizarding world's future, especially in the fight against Voldemort. So, he might try to find Harry not just to bring him back to Hogwarts, but also to protect him from whatever danger made him run away in the first place. He would be torn between his dislike for Harry and his understanding of Harry's significance.
Chapter 871, "Emergency Incident", is the clearest early answer because it turns Xue Wandeng's situation into a concrete plot event. The chapter gives readers a real answer by opening on He really didn't expect such a coincidental event to happen to him.
Look to Chapter 26 for the clearest answer. It begins with Shen Lan was bent over processing a large stack of press briefs on her..., keeps building through She was nearly forty years old, but because she took good care of herself..., and lands on If you think you can use our family connection to.
Chapter 704, "Even if I were a slave, I would be willing!", is the clearest early answer because it turns Chen's situation into a concrete plot event. Early on, Wu Daoshan looked at Zhao Lang in shock.. By the end, President Sun wiped the sweat from his forehead as he watched the two....
Chapter 889, "Nice to meet you for the first time, please take care of me!", is the clearest early answer because it turns Shen Lan's situation into a concrete plot event. Early on, She said why do other prisoners get a chance to go outside, while she....
Look to Chapter 17 for the clearest answer. It begins with Jiang Li glanced at Jiang Shixu, who was tense and anxious behind her, and..., keeps building through Okay, let's go eat." After speaking, she strode forward., and lands on I've been a mother for more than ten years but never tasted.
Chapter 851, "Peace Charm", is the clearest early answer because it turns Kexi's situation into a concrete plot event. The chapter turns that into something concrete by moving from She initially came with the expectation of becoming the Gu Family's... to The Old Madam also looked at Jiang Li..
Chapter 810, "I'm Waiting for Death", is the clearest early answer because the violence around Jiang Bufan becomes final instead of hypothetical. Early on, Jiang Buchen was about to go crazy from hunger.. By the end, Alright, he's satisfied even if he dies after eating such tasty food..
Chapter 875, "Isn't That Xu Mei's View?", is the clearest early answer because it turns Chen's situation into a concrete plot event. Early on, In the information network of the three people, Lu Yafei and Wan Jia....
Chapter 729, "Beauties Often Have Tragic Fates", is the clearest early answer because it turns Xu Ning's situation into a concrete plot event. The chapter gives readers a real answer by opening on In the deep of winter, the Capital experienced several heavy...
Chapter 796, "No Such Person?!", is the clearest early answer because it turns Jiang Li's situation into a concrete plot event. A useful checkpoint is the way the scene starts with The lively family reunion night came to an abrupt halt, and the...