The novel follows the journey of Ye Tian, an alchemy emperor reincarnated 10,000 years into the past when the human race faces extinction. With his second chance, Ye Tian uses his knowledge and alchemical skills to save humanity. He forms the Vanguard team, led by the formidable Fist King, to combat the threats from outer territories. As Ye Tian develops revolutionary alchemical techniques and refines arrays to strengthen human bodies, tensions rise with outer territory races. The Vanguard becomes feared as "human demons" for their prowess in battle. Meanwhile, Ye Tian's development of the Holy Ascension Pill and refining techniques transforms low-level humans into formidable warriors. Surprises arise when the refining array strengthens Chu Zheng and transforms Devine Fist into an Emperor-level powerhouse. Recognizing the danger of revealing such power, Ye Tian keeps it secret to avoid attracting Emperor-level enemies. As the human race grows stronger, they face challenges from the outer territories and the dangers of hidden enemies. But with Ye Tian's leadership and the strength of the Vanguard, humanity stands united against all threats, determined to secure their survival and future.