What are the drugs for the treatment of elevated blood uric acid?There were mainly the following types of drugs for the treatment of elevated blood uric acid:
1. ** Uric acid synthesis suppressing drug **:
- ** Allopurinol **: It is used earlier and can effectively suppress the production of both the enzyme and the enzyme, thereby reducing the production of uric acid. It can be used for hyperuricuria due to excessive production of uric acid, repeated attacks of gout, tophi, and other conditions. However, it is prohibited for people with severe liver and kidney function damage and obvious low blood clot. People who are positive for HLA-B5801 may have severe allergic reactions. The positive rate of this gene is higher in Asian people. It is recommended to do a genetic test before taking it. If it cannot be detected, start taking it from the minimum dose.
- ** Febustinat **: It is a selective yellowine oxi dase inhibition drug. It is suitable for hyperuricuria caused by gout. It is not recommended for people with hyperuricuria without symptoms of gout. The US Food and Drug Administration suggests that taking it may increase the risk of cardiovascular death. People at risk of cardiovascular disease need to be evaluated by a doctor before taking it.
2. ** Uric acid expelling drug **:
- ** Benbromarone **: It can block the reabsorption of blood uric acid by the kidney tubulae and correct the situation of insufficient blood uric acid secretion in the kidneys of patients with hyperuricemia. It is used for people with kidney failure with a clearance rate of more than 20ml/min, but it is prohibited for patients with acute gout, severe kidney function damage, or severe kidney stones. When taking it, drink a lot of water (more than 3000ml of water per day). Pay attention to liver function when taking the medicine. Discontinue the medicine immediately when there is loss of appetite, nausea, vomiting, and diarrhea.
- ** Probenecid **: Only used in people with primary hyperuricuria with normal kidney function.
3. ** New uric-lowering drugs **: For example, Rasburicase, which belongs to the uricase class, can decompose uric acid into a dissolved product and discharge it. However, it is prohibited for people who are allergic to this product, pregnant women, and G6PD-deficient people. There may be adverse reactions such as fever, nausea, vomiting, and rashes.
4. ** Alkaline urine medicine **: For example, it can be used when the urine is slightly acidic.
In addition, there were also some Chinese medicines that could help reduce blood uric acid. For example, Plantago Seed and Alisma in Tongfengding capsules could accelerate the secretion of uric acid. Huangbai and Smilax glabra could remove dampness and detoxify. Red peony could help with blood stasis and pain. Cyathula and Corymphala could dispel wind and dampness, dredge the channels and promote blood circulation, regulate qi and relieve pain. Qinjiao could dispel dampness, clear damp heat, and stop arthralgia. It is recommended to consult a doctor about the specific medicine to be used. Under the doctor's guidance, it should be used according to the doctor's advice.
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DescriptionIsobutyric acid, also known as 2-methylpropanoic acid, is a carboxylic acid with structural formula (CH₃)₂CHCOOH. It is a colorless liquid with a somewhat unpleasant odor. It is soluble in water and organic solvents. Isobutyric acid is an isomer of n-butyric acid. Wikipedia