Regions that held Unstable Anomalous Existential Domains were extremely dangerous to delve into as one would not normally use themselves, or in the case of an Imperium Royal, they wouldn't even send their Knights out first.
This was because eons of experiences showed how there could be Existential Distortion in regions such as these that could warp someone into distant foreign spaces, with the weavings shared by the Dominiums of some Imperium Royals before they died showing them being warped into the hunting grounds of Omniversal Pillagers, regions under the domains of other forces, or even areas where Existential Extremity Authorities were nullified!
If such a thing occurred, one could only wait for death.