AIDS is difficult to cure because the AIDS virus forms a viral reservoir in the immune cells of the human body.
This viral reservoir is difficult to clear, long-term standardized treatment of the AIDS virus can generally only suppress the virus from replicating, but it's difficult to destroy the AIDS viral reservoir.
Simply put, the AIDS virus is nestled within immune cells, duplicating hand in hand with the copying of immune cells.
The main target of it is CD4T lymphocytes, the CD4 molecules on the surface of CD4T lymphocytes are receptors for the AIDS virus, the virus envelope protein gp120 on the surface is its natural ligand, which is the key to the virus invading cells. When the gp120 of the virus surface binds to the CD4 of the cell, the virus enters the cell and integrates into the genome of the CD4T lymphocytes, becoming a provirus.