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Tian Xun told Lin Shen and Tian Xin that the progression to Nirvana is divided into two paths: one being Minor Nirvana, the other Great Nirvana.
Base Mutation and Ascension only require following established steps, and the risk is not significant.
However, Nirvana comes with considerable risk. If one chooses the path of Minor Nirvana, the risk is relatively lower. Even if the body sustains damage, it can recover, allowing for another attempt later on.
But if one opts for the Great Nirvana path, there might only be one chance. If failure occurs, the likelihood of survival is minuscule.
Minor Nirvana is relatively simple. It follows the same old path: elevate the Base Mutation Rate to 100%, increase the regeneration count of the Life Base as much as possible, and then find a Nirvana Egg. This grants the opportunity for Nirvana to take place.