The larger the body size, the slower the reaction speed. This is especially true for pythons, even more so for the ones that have just had their fill of food.
Facing Du You's brilliantly imprinted Disintegration spell, the huge python indeed sensed the danger but it was too late to dodge. The Titan Python, apart from its inherent abilities, had no other talents to offer.
As a result, the spell hit the python's head, and its upper body had shattered into pieces.
Within a flash, it turned into a light ball and fell into Du You's personal space. "The automatic retrieval function is really useful, I don't even have to go near them." Du You remarked to himself.
With every passing moment, Du You became more and more satisfied with his choice of the Disintegration Spell.