Stefan Salvatore and Katherine Pierce's son Zach Pierce-Salvatore has magic blood. His blood has the ability to cure vampirism. Stefan becomes human, so is Damon. And all Pierce-Salvatore enemies come to harm the Pierce-Salvatore baby. Caroline Forbes, who is the only vampire left, takes her nephew, changes his name and runs to New Orleans. In New Orleans, she takes the help of Klaus Mikaelson who also has a daughter. She falls for the man who has changed so much. Together, she and Klaus have to protect the Mikaelson Twins.