In my opinion, it's highly unlikely. Goku has mastered multiple forms and techniques that give him a wide range of powers. Saitama's one-punch style might not be effective against Goku's diverse skills and battle experience.
I don't think there's a clear winner. Both Manga Goku and Manga Saitama have unique and powerful abilities. It could come down to strategy, luck, or even the author's imagination!
In the manga, Gohan never managed to defeat Goku. Their battles often ended with Goku coming out on top or the fight being interrupted for some reason.
Goku's victory over Hit in the manga was the result of his perseverance and the ability to surprise Hit with unexpected moves. Also, his experience in battles played a significant role.
In my opinion, Saitama doesn't have a chance against Goku. Goku has mastered multiple forms of Super Saiyan and has fought incredibly powerful foes across multiple universes. Saitama's strength is impressive, but it's not on the same level as Goku's.