In my opinion, it's highly unlikely. Goku has mastered multiple forms and techniques that give him a wide range of powers. Saitama's one-punch style might not be effective against Goku's diverse skills and battle experience.
I don't think there's a clear winner. Both Manga Goku and Manga Saitama have unique and powerful abilities. It could come down to strategy, luck, or even the author's imagination!
His father might be extremely proud. After all, Goku has achieved so much, like protecting the Earth multiple times. He would look at Goku with admiration for his strength and kindness.
I think Saitama is stronger. His power is seemingly limitless and he has never struggled in a fight. Goku, although powerful, has had many intense battles where he was pushed to his limits.
Goku would be a mix of angry and worried. His Saiyan blood would make him want to rush into battle with Raditz right away. But he also knows how dangerous Raditz is, so he might first try to gather some allies, like Piccolo. He'd be constantly thinking about Gohan and how to rescue him as quickly as possible.
In my opinion, Saitama doesn't have a chance against Goku. Goku has mastered multiple forms of Super Saiyan and has fought incredibly powerful foes across multiple universes. Saitama's strength is impressive, but it's not on the same level as Goku's.
Chi - Chi might also be heartbroken. She loves Goku deeply despite his flaws. In fanfiction, she may initially be in denial, thinking that Goku will come back soon. But as time passes, she realizes that he may not return, and this could lead to a deep sense of sadness and loneliness. She has to then figure out how to raise their children on her own.
The villains would have a mixed reaction. Some of the more power - hungry ones might see this as an opportunity to join forces with Saitama and cause even more chaos. However, there would also be villains who are afraid of Saitama's power, even if he's on their side now. They would be worried that he could turn on them at any moment. Overall, Saitama turning evil would completely disrupt the existing power dynamics in the One Punch Man world.