Ophelia's story is one of heartbreak and tragedy. She is a pawn in the larger drama of Hamlet. Her love for Hamlet is not reciprocated, and the political and emotional turmoil around her push her over the edge, resulting in her tragic end.
The story behind Ophelia is complex. She is caught in the web of Hamlet's inner turmoil and the political drama at the Danish court. Her love for Hamlet is unrequited, and the stress and chaos around her drive her to insanity. Eventually, she drowns, adding to the tragedy of the play.
Another theme is time - related. Since Homura has the ability to manipulate time in the show, many fanfictions play with this concept in relation to her relationship with Madoka. For example, stories might involve Homura going back in time to save Madoka in different ways or dealing with the consequences of her time - traveling on their relationship.