Generally, Miles and Gwen's relationship in the comics is more about friendship and working together as superheroes. Romance isn't a major focus, so they don't typically 'get together' in the conventional sense.
Langa and Reki do end up together in the manga. It's a satisfying conclusion for fans who have followed their story closely. The plot twists and turns lead to this heartwarming ending where they are united.
In the manga, Ishida and Shoko's relationship develops gradually and eventually they end up together. It's a heartwarming conclusion for their story arc.