Penguin and Riddler are typically not friends. They often operate independently and may even compete or have conflicts with each other in the comic universe.
Deadpool and Wolverine have a unique bond. While not always traditional friends, they have shared adventures and shown care for each other in their own way, despite their clashing personalities.
Sure, The Flash and Green Arrow are friends. They share common goals and help each other out on many occasions. Their friendship adds depth to the comic universe.
Clark and Lex were friends at the beginning in the comics. But as the story progressed, Lex's character changed, and they became enemies. This transformation was driven by Lex's mistrust and his own ambitions.