We can assume that Isaac in '600 lb life isaac's story' is a person whose life is being explored in the context of extreme obesity. He may be an ordinary person who, for various reasons such as poor diet, lack of exercise, or genetic factors, has reached a weight of 600 lbs or close to it. His story is likely to be about his day - to - day existence dealing with the consequences of his weight, his relationships with family and friends which are probably affected by his condition, and his pursuit of a healthier lifestyle.
There were many famous sayings of Isaac Asimoff, and the most famous one was:
If there is a next life, I want to be a tree standing in a posture that will never be sad or happy.
This sentence came from Asimoff's book, Base, which expressed his yearning for the future and his reverence for life.
One common theme could be loyalty. Given the nature of Daryl Dixon's character in the original show, loyalty to friends or comrades like Gene Dixon and within the context of Trinity might be a big part of the fan fictions.
Daryl Dixon isn't gay in the comics. The storylines mainly revolve around his adventures and struggles in a post-apocalyptic world, not his sexual orientation.
It depends on their popularity and the creativity of fans. If people are really into their characters and potential relationship, fanfiction could definitely exist.