Tony Stark has met his demise in some comic versions. But keep in mind that comics often have alternate realities and potential resurrections or different story continuations.
Pepper Potts could be a big help. She knows Tony so well, and she could try to jog his memory by showing him things from their past together, like pictures or mementos. Rhodey could also be there for him. He could tell Tony stories about their military days and how they became friends, which might trigger some memories.
One common character paired with him is Bruce Banner. They could be gaming buddies, with Bruce using his scientific knowledge to help Tony improve his games or vice versa. Another is Pepper Potts. She might be shown as someone who tries to get Tony to take a break from his intense gaming sessions.