Losing urine refers to the disease of urinating by oneself, that is, involuntarily involuntarily incontinent and automatically urinate. This kind of symptoms could be seen in kidney deficiency, bladder failure, old age qi deficiency, high fever coma, stroke, epilepsy and other diseases. Typhoid fever could also appear in critical illness. It was mentioned in Shang Han Lun that the reason for the loss of qi may be due to water deficiency and nutrient exhaustion, resulting in the failure of kidney qi storage.
It's not a straightforward yes or no. The fate of Red in a manga could be influenced by many factors such as the genre, the theme, and the development of the story. So, we can't say for sure without more details about the particular manga.
Once Luffy is kidnapped, Doflamingo might try to break Luffy's spirit. But Luffy being Luffy, he would resist. Meanwhile, the crew's journey to rescue him could be filled with many obstacles. They might encounter other pirates or marines who are either allies or enemies of Doflamingo. The crew would have to fight their way through and use their combined skills to reach Luffy. For example, Brook could use his soul powers to pass through walls and scout ahead.
Power is a very common theme. Since Doflamingo is a powerful character, many fanfictions explore how he uses or abuses his power. Another theme is redemption. Some writers like to imagine if he could be redeemed or not.