I'm not sure which anime you're referring to. If you can provide more information such as characters, background, or title, I will try my best to provide you with a more accurate answer.
The information you provided was too little for me to identify which animation you were referring to. You can provide more details so that I can better answer your question.
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Animation was a combination of animation and manga, usually with independent storylines and characters, but also freely switched between animation and manga. An anime could be an independent work or a part of other media such as novels and games. In addition, anime was also often referred to as "animated series","animated series", or "animated short films" to distinguish it from other media forms such as movies and television dramas.
The 'drop' in the title might refer to a physical drop like a raindrop or a drop of blood. Maybe the novel is a mystery where a single drop found at a crime scene is the key to solving the whole case. It could also be a metaphor for a small action that has large consequences in the story.
It depends. Sometimes stories labeled as 'Drop Out' might be based on real events, but they could also be fictional creations inspired by common themes.