One characteristic is that it often contains romantic or more sensual elements related to the characters of Trigun. It may focus on relationships between characters like Vash and other main characters in a more intimate way.
Overall, Trigun Stampede adheres closely to the manga. Some minor details might differ for the sake of the adaptation's flow and visual presentation, but the core remains the same.
The Trigun manga has a considerable length. It consists of multiple volumes and chapters, but the exact number can vary depending on the specific edition and printing.
One common theme could be the clash of different worlds. Since Naruto is a ninja - based world and Trigun has its own unique post - apocalyptic - ish world, seeing how the characters from both interact and deal with the differences in cultures and powers is often explored.