Well, first, sketch the basic outline of the eyes and nose. Then, play around with the expressions - maybe make one eye wink or give the nose a funny tilt. Use bold lines and bright colors to make it stand out.
The key to a funny social distance cartoon could be in showing the contrast between how serious the situation is and the comical ways people deal with it. Maybe it features animals or objects behaving as if they need to keep social distance too, which adds to the humor.