Another scenario could be that there is an antagonist in the story, someone who doesn't like Saphie because of her unique appearance. Jojo, being Saphie's friend, stands up to this antagonist. This results in Jojo getting hurt in the confrontation. The story could then focus on how Saphie tries to help Jojo recover and seek revenge on the one who hurt him.
It could be another animal in the neighborhood. Maybe there's a territorial cat that doesn't like Jojo and Saphie being around. This cat could attack Jojo when they cross into its territory.
Maybe Joho's sickness could be a magical ailment that only Saphie, the one - eyed cat, can cure. For example, Saphie might have some special powers that are connected to her one eye, like the ability to see into the spirit world where the source of Joho's illness lies.
The main characters are clearly Joho and Saphie. Joho is the one who gets sick, so he's likely to be at the center of the story's problem. And Saphie, the one - eyed cat, seems to be an important figure who will probably play a big role in dealing with Joho's sickness.
Perhaps she gets hurt while trying to protect someone she cares about. She could be shielding a friend from an attacker's blow, and in the process, take the brunt of the injury herself. This would then set up a story of her recovery and the revenge she might seek on the one who caused the harm.
Maybe Jacob gets into a fight and gets physically hurt. For example, he could be punched during an argument in the story.
Well, he might break a bone. Maybe his ankle while skating fast.
In this fanfiction, T Challa might get hurt during a battle. Maybe he faces a powerful enemy who manages to wound him. This could lead to other characters coming to his aid and a story of recovery and resilience.
Well, Naruto might name the cat after one of his ninja moves, like Rasengan. And the cat could become his little sidekick, following him around the village. It could even learn some ninja - like behaviors from Naruto.
In this fanfiction, Everest might be hurt during a rescue mission. Maybe she slips on the ice while trying to reach a stranded pup or a person. The other Paw Patrol members would then spring into action to help her. They could call Ryder for extra assistance or use their special skills to get her to safety and tend to her injuries.
Naruto might get hurt during a mission with Kaka - naru. Kaka - naru could then carry Naruto back to safety and tend to his wounds. This simple act of care can strengthen their bond.