In a Virgil Flowers novel, 'Holy Ghost' might be a key part of the narrative. It could be a symbol of hope, or perhaps a clue in a larger mystery. Since Virgil Flowers novels often involve complex mysteries and investigations, the 'Holy Ghost' could be something that is initially very difficult to understand. It might be a reference to an old legend or a historical event in the fictional world of the novel. The characters in the story may be either in search of it, or it may be something that is causing problems for them. For instance, it could be a valuable artifact with a religious backstory that has been lost or stolen, and Virgil Flowers is on the case to find it and figure out its significance.
The 'Holy Ghost' in the Virgil Flowers novel could be a specific concept, a character, or an element that plays a significant role in the story's plot, setting, or themes. Without having read the exact novel, it's hard to be more specific.