I think Lex Luthor and Crowley would be an amazing pairing. Lex is always looking for power and knowledge, and Crowley, as a demon, has a lot of both. They could make a dangerous alliance, with Lex thinking he can control Crowley but really being played. Also, Lois Lane and Castiel. Lois is feisty and curious, and Castiel is this otherworldly angel. Their interactions would be really fun to write, as Lois tries to figure out what's up with this strange 'angel' guy." "Answer3": "One of the most interesting pairings could be Oliver Queen from Smallville and Bobby Singer from Supernatural. Oliver is a skilled archer and fighter, while Bobby is a knowledgeable hunter. They could share their skills and experiences. Also, Kara Zor - El and Gabriel. Kara has her superpowers and is from another planet, and Gabriel is a trickster archangel. Their meeting could lead to some really wild and unpredictable situations, full of humor and action.
Definitely Clark Kent and Dean Winchester. Clark with his superpowers and strong moral code, and Dean with his tough - as - nails hunting skills and loyalty. They could have some great banter as they come from such different worlds but find common ground in protecting people. Another interesting pairing could be Sam Winchester and Chloe Sullivan. Sam's intelligence and knowledge of the supernatural could pair well with Chloe's investigative skills.