The relationship between Issei and Sasuke would be very different. Sasuke, used to Naruto's determination to bring him back, would now face Issei. Issei might not have the same emotional connection to Sasuke as Naruto did. Instead, he could be more interested in Sasuke's power. With Sakura, Issei's more flirty nature could make her either annoyed or intrigued, quite unlike Naruto's one - sided love for her.
If Issei replaces Naruto, the relationship with the village elders would be altered. Naruto was seen as a troublemaker but also a potential savior. Issei, with his different background and abilities, would be an enigma to them. They might be more suspicious of him at first. And in terms of his relationships with other ninja, like Kakashi, Kakashi would have to adjust to Issei's fighting style and personality. Issei may not respond to Kakashi's teachings in the same way Naruto did, leading to a different dynamic in their mentorship.
The relationships in the story would change significantly. Issei's presence instead of Naruto would mean different interactions with the Akatsuki. The Akatsuki might view Issei as a new and unknown threat or opportunity. In his relationships with the other Jinchuriki, Issei would not have the same shared experiences as Naruto. He might approach them with his own motives based on his Devil - related knowledge. Also, his relationships with the various ninja clans in the village would be different. For example, the Hyuga clan might be more cautious around Issei compared to Naruto due to his foreign nature and powers.
In a fanfiction where Issei turns into a dragon, his relationships would be in flux. His relationship with his mentors or those he looks up to might change as they now see him as a different kind of being. They might treat him with more caution or more respect depending on how they view dragons. His friendships with his peers would also be altered. Some might see him as a weapon to be used in their battles or struggles, while others would see him as a friend in need of support. Romantically, if he had feelings for someone, that person would have to deal with the fact that Issei is no longer fully human. There could be jealousy from others who might want to be with the powerful dragon - Issei, or there could be newfound admiration from those who previously overlooked him.
His relationship with Sasuke would likely become more of a partnership. As Hokage, Naruto would need Sasuke's skills and knowledge to protect the village. They would probably have regular meetings to discuss security and other important matters.
Naruto's relationships would experience significant shifts. With his friends, they would need to be more patient and creative in their communication. For example, Shikamaru, who is usually laid - back, would have to be more active in ensuring Naruto is included in conversations. Naruto's relationship with the Hokage would also be different. The Hokage would need to find new ways to give Naruto missions and communicate orders. In his romantic relationships, like with a potential partner, there would be a whole new dynamic. The partner would need to be understanding and learn to communicate in a way that suits Naruto's deafness, which could lead to a deeper and more empathetic connection.
With his female friends, there could be a shift in the dynamic as well. They might be more open with him now that he's a girl, sharing secrets and experiences that they previously wouldn't have. He could also become more involved in 'girl - only' activities, strengthening those friendships in new ways.
His relationship with Sasuke could be different. Maybe Sasuke would be in awe of Naruto's new powers at first. They might have less of a rivalry and more of a partnership from the start, with Sasuke seeing Naruto as a step ahead in power and knowledge.
In terms of his romantic relationships, if there were any potential love interests, they might be more hesitant. However, Naruto's determination and positive attitude could still win them over. His relationships with his teammates from Team 7 would likely shift. They would need to adjust their battle strategies to account for his one - eyed state. His bond with Hinata could also be tested as she might worry more about his safety and his ability to protect himself and the village.
His relationship with his friends would be strained. For example, Sasuke might notice a change in Naruto's attitude towards him and others. Naruto may start to avoid his friends as he no longer trusts them like he used to.
His relationship with Sakura would be very different. Instead of the one - sided love she had for Sasuke, she might be both attracted and repelled by Naruto's new anti - hero persona. She could see the good in his intentions but be horrified by his methods.
Naruto's relationship with his sensei, like Kakashi, would also change. Kakashi would be extremely vigilant and try to train Naruto to control the Sephiroth - like powers. He might also be researching about this strange phenomenon. As for his friends in the village, some might be afraid of him, while others might see it as an opportunity for the village to become stronger. But overall, Naruto would feel a bit isolated as he's different now.
His relationships would change a great deal. He'd probably form a father - son type of bond with the Raikage. With the other Cloud ninjas, he'd start as an outsider but gradually earn their respect through his skills and determination. His relationship with his friends in Konoha might become more complex as he now has a new allegiance to the Hidden Cloud.