I think Clary from Shadowhunters would be really interesting. She's a strong - willed and powerful shadowhunter. If she were to cross paths with the Twilight characters, her inquisitive nature would lead her to try and understand their world. And her skills as a shadowhunter could be put to the test when dealing with the vampires and werewolves in Twilight.
Edward would be really interesting. His brooding and mysterious nature from Twilight would contrast sharply with the often over - the - top and energetic world of Glee. He could bring a sense of depth and angst to the Glee club. His musical talent, which was hinted at in Twilight, could be explored more fully in the Glee setting. He might struggle with fitting in, not because he's not talented, but because of his vampire secrets.
Alice from Twilight could be a fascinating character to focus on. Her ability to see the future could play an interesting role in a crossover. She could either help or hinder the Ghost Adventures crew in their investigations. Maybe she sees something in the future that involves the ghosts and tries to prevent or encourage the crew's actions.
Alucard from Hellsing would be really interesting. He has such a long and complex history, and his powers are very different from the Twilight vampires. Putting him in a situation with the Twilight characters would create a lot of drama. For example, his non -chalant attitude towards killing and his dark sense of humor would contrast greatly with the more brooding and 'good -guy' Twilight vampires.
Luna Lovegood would be an unexpected but fascinating choice. Her unique perspective and belief in all kinds of magical creatures could make her very open - minded about the vampires and werewolves in the Twilight world. She might see them as just another type of magical being and try to find common ground, which could lead to some really interesting interactions and storylines.
Raphael could be really interesting. In the 2003 version, he is hot - tempered and tough. In the 2012 version, he also has a strong personality. Seeing how he reacts to his counterpart and how they might either clash or bond could be a great focus. Maybe they have a friendly rivalry as they compare their fighting skills.
Ross could be really interesting. Since he's an archaeologist, in a crossover with a show like 'Indiana Jones' (in a fanfiction sense), he could go on an adventure with Indiana Jones. Ross would bring his academic knowledge while Indy would have the practical experience. Their interactions would be filled with Ross trying to over - analyze everything and Indy just wanting to get the job done.
Chiaki Nanami could be an excellent choice. She is the Ultimate Gamer, so if you cross her with a digital or virtual world, there are so many possibilities. She could use her gaming skills to navigate through a new digital realm, like a Matrix - like world. Her calm and intelligent nature would also make her a great character to lead the group in a crossover situation. She could figure out the rules of the new world quickly and help the others adapt.
I think it would be Loki. In this crossover, Loki could use his trickery to manipulate the Twilight vampires. He might see them as a new tool to achieve his goals. He could pretend to be on their side and then turn on them when it suits him. His magic and cunning would add a whole new level of chaos to the story.
Definitely Damon Salvatore. He's the bad - boy vampire with a heart of gold (sometimes). In a crossover, he'd be a wild card. He has his own sense of justice and loyalty, but also a devil - may - care attitude. He could get into all sorts of trouble in the world of the Originals. His sarcastic remarks and his ability to charm his way out of (or into) situations would make for some great scenes. He might also form an unlikely friendship or rivalry with one of the Originals, like Kol perhaps. His backstory and his experiences in 'The Vampire Diaries' would contrast and collide in interesting ways with the Originals' world.