A jealous student at Hogwarts could be an antagonist. This student might be envious of the attention Harry's sister gets because of her famous brother. So, they try to play mean pranks on her or spread false rumors.
Voldemort's remaining followers could be antagonists. They might target Harry's little sister thinking they can use her to get to Harry. They could try to kidnap her or use dark magic on her.
Voldemort's remaining followers could be the antagonists. They might see Harry's little sister as a way to get revenge on Harry or as a potential tool for their dark purposes.
In a 'Harry Potter and His Little Sister' fanfiction, the sister could be a new student at Hogwarts when Harry is in his later years. She struggles to fit in because of being Harry Potter's sister. Harry has to help her deal with the pressure, make friends, and also face the threat of a new dark wizard who has a vendetta against the Potter family.
It could be Draco Malfoy. He might not like the idea of Harry getting a second chance at the OWLS and tries to sabotage him. Maybe he spreads rumors about Harry not being worthy of a retake.
One possible antagonist could be a jealous rival among the pirate gangs. This person might envy Harry Hook's sister's skills or popularity. Additionally, a corrupt official in the Isle of the Lost who wants to keep the status quo and sees her as a troublemaker could be an antagonist. Also, if there are any ancient curses or dark spirits on the isle, they could turn against her and try to stop her from achieving her goals.
There could be some old - fashioned professors at Hogwarts who are against Harry's unorthodox ways of making his mark. They believe in the old - established ways of teaching and practicing magic and see Harry as a troublemaker who is disrupting the order of things at the school.
It could be a group of dark wizards who are jealous of Harry's status and see Lemon as a way to get to him. They might try to kidnap her or manipulate her to get Harry to do their bidding.
Their parents' old friends could be main characters. They might come to check on Harry and his sister, bringing gifts and stories about their parents. These friends could offer guidance and protection when needed.
The Thalmor could be great antagonists. Their strict control over magic and their anti - human beliefs could put them at odds with Harry. They might see his different form of magic as a threat to their power in Skyrim.
It could be a new dark wizard who wants to make a name for himself. He sees Hogsmeade as an easy target to show his power. He starts by causing small disruptions like making objects in the shops move on their own and then escalates to more dangerous attacks that Harry has to stop.
The Death Eaters could be the antagonists. Even though Voldemort is gone, some of his followers might not want Harry to succeed in building a starship as they fear it could bring more power to Harry and his friends, and they still hold grudges against him.