Itachi himself could be seen as the main antagonist in this scenario. After all, he is the one doing the kidnapping.
Itachi himself could be seen as the main antagonist in this scenario as he is the one performing the kidnapping. His actions are against Sakura's will and are likely to cause distress and conflict.
Itachi himself could be seen as the main antagonist in this scenario as he is the one carrying out the kidnapping. He is acting against Sakura's will and causing a dangerous situation for her.
It could be that Itachi is being controlled by some dark force or an enemy. He doesn't really want to harm Sakura but has no choice. The fanfic might then focus on Sakura trying to figure out how to break the control on Itachi while also trying to escape from the situation. She could use her medical ninjutsu skills to her advantage in some way.
Another possibility is that an old enemy of the Uzumaki clan resurfaces. They use Itachi's complex relationship with the village and his own motives to manipulate him into kidnapping fem Naruto. So, this old enemy would be the main antagonist as they are the ones driving the overall conflict.
A rogue ninja who wants to steal the power of the contract for his own evil purposes could be the main antagonist. He might be jealous of the connection between Sakura and Itachi and wants to break it to gain the abilities they could potentially unlock together.
In such a fanfic, perhaps Itachi kidnaps Sakura for some strategic reason related to the shinobi world. Maybe he thinks Sakura has some knowledge or ability that could be useful to his goals. For example, her medical skills could be crucial for treating someone in his group.
Another possibility is a new villain who has the power to control Bucky's actions. This villain could be after Tony for his wealth or his influence in the superhero community. The villain forces Bucky to do the dirty work while staying in the shadows.
It could be Orochimaru. He might manipulate Gaara into kidnapping Sakura. Orochimaru could have his own devious plans for Sakura, like using her medical knowledge for his experiments. So, he uses Gaara's power and his somewhat unstable mental state at times to achieve his goal. Then Sakura and Gaara would have to team up to fight against Orochimaru.
It could be Orochimaru. Since he's always after power and Naruto, with Itachi's training, would become a more appealing target. Orochimaru might see Naruto as a threat to his plans of obtaining all the jutsu in the ninja world.
Maybe the main antagonist is an evil organization that has been secretly infiltrating the village. They target Sakura because of her skills and knowledge. They deceive her into believing that her village is the real enemy, causing her to betray her comrades.