Well, in the mainstream, Spider Man is generally an ally of the Avengers. So in this fanfiction, the very fact that he hates them is a huge deviation. In the regular stories, they work together towards common goals. But here, it's a completely different dynamic.
Well, maybe he's got some secret mission that he doesn't want the Avengers to interfere with. You know, like protecting a particular person or some crucial information that he thinks the Avengers might mess up if they get involved.
Spider - Man would likely be confused at first. He respects the Avengers and can't understand why they are suddenly after him. He might try to talk to them, to explain that he's innocent. For example, he could swing up to Captain America and start pleading his case.
In the fanfiction, it could be that Spider Man has a personal vendetta against one of the Avengers members. For example, if one of them had a past with a villain that Spider Man has a strong connection to, like if an Avenger unknowingly helped the villain in the past, Spider Man might transfer his hatred for that villain to the Avenger and by extension, the whole team.
His relationship with Black Widow could also be affected. Black Widow has a long history with Shield. Spider Man might view her with distrust, which could lead to some interesting and conflict - filled interactions in the fanfiction. He may not be as willing to team up with her as he would be in the normal Marvel universe.
One interesting storyline could be Spider - Man teaming up with the Avengers to fight a new super - villain that's a combination of different powers they've faced before. For example, a villain with the strength of the Hulk and the mind - control abilities of Loki.
One interesting storyline could be Spider - Man having to use his unique abilities to solve a mystery within the Avengers' headquarters. His agility and spider - sense might lead him to discover a hidden threat that the other Avengers overlooked.
In fanfiction, the trailer might inspire the Avengers. Spider - Man's youth and energy could motivate them to step up their game. They might see his unique abilities and think about how to incorporate new strategies into their own fighting styles. Also, it could lead to some of them wanting to meet Spider - Man and offer their help or form an alliance.
In the original story, May is a loving and supportive figure in Peter's life. So this fanfiction is a complete departure as it portrays her in a negative and abusive role. It changes the dynamics of Peter's home life, which is usually a source of comfort and moral guidance in the normal Spider - Man narrative.
In the original story, Naruto loves ramen. It's a big part of his character. So in this fanfiction, it's a complete opposite. It changes the fundamental aspect of his relationship with food.
In the original story, Hermione and Ron have a complex relationship that is full of love, albeit with some bickering. Fanfiction that has Hermione hating Ron completely goes against this fundamental aspect. Their friendship and later romantic relationship in the original are based on mutual understanding and shared experiences. So this kind of fanfiction takes a very different turn.