It could also be an old and powerful magical creature that has been awakened by some dark magic. This creature sees Harry as a threat to its existence because of his mastery of magic and decides to target him. For instance, a dragon that has been enchanted with dark magic to be more intelligent and malicious.
Voldemort could still be the main antagonist. Even if Harry is a 'child of magic' in a different way, Voldemort would still see him as a threat to his power and his vision of a pure - blood dominated wizarding world.
Perhaps an ancient spirit that has been awakened by the imbalance in the life - death cycle due to Harry becoming the Master of Death. This spirit sees Harry as the cause of the chaos and tries to destroy him to restore the balance in a way that is harmful to the wizarding world.
A powerful, ancient sorcerer could be a great main antagonist. This sorcerer could have been locked away for centuries but has now broken free and wants to take over the universe from the Master of the Universe. He could have dark magic that the Master has never faced before.
The main antagonist could be Master. Since the title mentions Master, it's likely that this character has a lot of power and influence in the merchant world. They might be using their position to cause harm or manipulate things in a way that leads to death, which would make them a natural antagonist for Harry and Tony to oppose.
It could be a rogue ninja who has also mastered some form of insect - based jutsu and wants to use it to take over the Hidden Leaf Village. He sees Naruto as a threat to his plans since Naruto is becoming the master of insects.
It could be an archaeologist who has been corrupted by the power of an ancient artifact related to the mummy. This archaeologist wants to use the mummy's power for his own gain, like becoming immortal or ruling the world. He would be constantly trying to stop Harry from helping the mummy.
It could be a powerful dark wizard who has also gained some supervillain - like powers. This antagonist might be jealous of Harry's newfound superhero status and wants to destroy him.
It could be a powerful dark wizard who has infiltrated the games under a false identity. This wizard might have a vendetta against Natsu or his guild and wants to disrupt the games and cause chaos.
It could be Voldemort who somehow manages to cross over into the Star Wars universe. He might see the power of the Force as something to be harnessed for his own evil purposes. His dark magic would be a great contrast to the light - side teachings of Yoda, and Harry and Yoda would have to team up to stop him.
A powerful and evil Pokémon trainer could be the main antagonist. This trainer might have a team of extremely strong and rare Pokémon that he has trained in unethical ways. He could be after some sort of power or rare item that would give him even more control over Pokémon, and Ash stands in his way of getting it.