A really interesting pairing could be Alice Cullen and Cisco Ramon from The Flash. Alice has her precognitive abilities in Twilight, which could be really useful in The Flash's world where they often face unexpected threats. Cisco, with his technological genius, could be fascinated by Alice's power. They could work together to predict and prevent disasters. Maybe Cisco could even try to create a device to enhance or mimic Alice's power, which would add a whole new dimension to the crossover fanfiction.
Edward Cullen and The Flash would make for an exciting pair. Edward has his vampire powers, including super - strength and enhanced senses. When combined with The Flash's super - speed, they could be an unbeatable team. Imagine them racing against each other at first, testing each other's limits, and then realizing they can achieve more together. Also, Edward's brooding nature and The Flash's more upbeat and positive attitude would create a great contrast in the story.
Another interesting pairing could be Alice Cullen and Sookie Stackhouse. Alice has her visions of the future, and Sookie has her mind - reading ability. They could team up to solve some mystery that involves both the 'Twilight' and 'True Blood' worlds. Maybe they could use their powers to prevent a war between the two different vampire factions.
I think pairing Hermione with Edward would be really interesting. Hermione's intelligence and love for knowledge could be contrasted with Edward's brooding and his vampire nature. She could be intrigued by his abilities and he by her magic.
Jacob and Ron would be a great pairing. Jacob's easy - going nature and loyalty as a werewolf could mesh well with Ron's sense of humor and his own loyalty to his friends. They could get into all sorts of misadventures, like trying to combine wizard food with werewolf hunting techniques or something equally absurd.
Edward and Cleo would also be a fascinating pair. Edward's brooding and mysterious nature combined with Cleo's kind - hearted and sometimes naive mermaid self could lead to some really interesting interactions. Maybe Edward could be intrigued by Cleo's water - based powers and Cleo could be both scared and attracted to Edward's vampire side.
Inuyasha and Edward would be really interesting. Inuyasha is brash and hot - tempered, used to fighting his enemies head - on. Edward, on the other hand, is more reserved and calculating. Their different approaches to handling threats and their unique supernatural abilities would create a lot of tension and also some interesting interactions.
Evie and Rosalie would also make an interesting pair. Evie is all about beauty and fashion, while Rosalie has her own sense of elegance. They could have a love - hate relationship. Evie might be a bit intimidated by Rosalie's beauty at first, but then they could find common ground in their strong personalities and start to respect each other.
Definitely Dean Winchester and Barry Allen. Dean has his tough - as - nails hunter attitude and Barry is the optimistic speedster. They could have some great banter while on a mission together. For instance, Dean might be constantly amazed at Barry's speed but also make fun of how he doesn't know how to handle a real weapon like a gun.
Harry Potter and Edward Cullen would be an interesting pair. Harry has his own inner struggles with the power of the Dark Lord inside him, and Edward has his battle with his vampire nature. They could learn from each other about self - control and using their powers for good. Also, they both have a strong sense of protecting their loved ones.
Dumbledore and Carlisle Cullen would also be a fascinating pair. Dumbledore is a wise and powerful wizard, and Carlisle is an old and moral vampire. They could have deep discussions about life, death, and the responsibilities that come with their powers. They might also collaborate to find solutions to problems that affect both their worlds.
Ron and Jacob could be a fun pair. Ron is a bit of a food - loving and sometimes clumsy character, while Jacob is a hot - headed werewolf. They could start off bickering but then end up becoming friends. Ron could introduce Jacob to some of the delicious wizarding treats, and Jacob could show Ron how to embrace his more wild side in a different way than magic allows.